![]() To obtain a multiple dose simulation model, or substitute the compound to obtain a simulation model for another drug. Just substitute the individual by a suitably parameterized virtual human population and obtain a first in man simulation model.įurther substitute the formulation, to obtain a controlled-release per oral simulation model, substitute the protocol The advantage of building blocks is that they can be reused.įor example, after having established a model for a drug after single dose intravenous administration to an animal species, Building blocks from these groups are combined to produce a model. PK-Sim® uses building blocks that are grouped into Individuals, Populations, Compounds, Formulations,Īdministration Protocols, Events, and Observed Data. This way customized systems pharmacology models may be set up to deal with the challenges of modern drug research and development. Thereby allowing full access to all model details including the option for extensive model modifications and extensions. More importantly, PK-Sim® is fully compatible with the expert modeling software tool MoBi®, to account for important differences between small and large molecules. Unlike most PBPK modeling tools though, PK-Sim® offers different model structures to choose from,Į.g. Like most PBPK modeling tools, PK-Sim® is designed for use by non-modeling expertsĪnd only allows for minor structural model modifications. Relevant generic passive processes, such as distribution through blood flowĪs well as specific active processes such as metabolization by a certain enzymeĪre automatically taken into account by PK-Sim®. To allow for fast and efficient model building and parameterization is provided. Moreover, access to different PBPK calculation methods That are contained in the integrated database. The most common pre-clinical animal models (mouse, rat, minipig, dog, and monkey) It enables rapid access to all relevant anatomical and physiological parameters for humans and PK-Sim® is a comprehensive software tool for whole-body physiologically based pharmacokinetic modeling. ![]()
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